The two-compartment recirculatory pharmacokinetic model'an introduction to recirculatory pharmacokinetic concepts

The two-compartment recirculatory pharmacokinetic model--an introduction to recirculatory pharmacokinetic concepts.

BACKGROUND Some limitations of traditional ("mamillary") compartmental pharmacokinetic models of anaesthetic related drugs arise from representing the blood as a central compartment. Recirculatory pharmacokinetic models overcome these limitations. It is proposed that the simplest recirculatory model has only two compartments, and that understanding the properties of this model is a useful intro...

Basic concepts of recirculatory pharmacokinetic modelling.

Clinical Pharmacokinetic Applications of Recirculatory Models

Charge Density Enhancement due to Recirculatory Flow

This paper develops a system model for electrification in a flow loop and investigates volume charge accumulation due to recirculatory flow between a charge source and several charge relaxation regions. Enhanced charge densities are predicted when the source is a filter and the residence time in the relaxation regions is small compared to the liquid dielectric relaxation time. Small scale flow ...

First-pass lung uptake and pulmonary clearance of propofol: assessment with a recirculatory indocyanine green pharmacokinetic model.

BACKGROUND The principal site for elimination of propofol is the liver. The clearance of propofol exceeds hepatic blood flow; therefore, extrahepatic clearance is thought to contribute to its elimination. This study examined the pulmonary kinetics of propofol using part of an indocyanine green (ICG) recirculatory model. METHODS Ten sheep, immobilized in a hammock, received injections of propo...